Tamoghna Chowdhury

The paper determines the structure of the apo-PIWIL4-HSP90 complex and shows it adopts an open conformation distinct from piRNA-bound PIWI.

The paper shows TPR is required for early NF-κB activation during oncogene-induced senescence, leading to cytoplasmic chromatin fragment formation and SASP activation.

The paper investigates the role of XRN-2 endoribonuclease activity in dauer state maintenance and post-dauer life cycle continuity in C. elegans, finding that its disruption leads to metabolic and developmental defects.

The paper identifies XRN-2 as an endoribonuclease involved in 5-end processing of precursor piRNAs in C. elegans, revealing its role in piRNA maturation and function.

The paper shows XRN2 degrades specific tumor suppressor miRNAs, affecting cancer cell behavior and patient survival.