NRF2 translation block by inhibition of cap-dependent initiation sensitizes lymphoma cells to ferroptosis and CAR-T immunotherapy
Paola Manara, Austin Daniel Newsam, Venu Venkatarame Gowda Saralamma, Tyler Andrew Cunningham, Drew Lazenby, J.J.David Ho, Marco Vincenzo Russo, Abdessamad Youssfi Alaoui, Dhanvantri Chahar, Alicia Bilbao Martinez, Nikolai S. Fattakhov, Alexandra Marie Carbone, Olivia Barbara Farag, Alexa Marie Barroso, Kyle S. Hoffman, , Jonathan Harry Schatz
This study shows that inhibiting cap-dependent translation in lymphoma cells increases sensitivity to ferroptosis and CAR-T therapy by reducing NRF2 expression.
Cancer Research · Jul 31, 2025Peer-reviewedCancer Biology