Author

Lewis Timimi

The Francis Crick InstituteORCID 0009-0004-7243-5983Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Beatriz MontaneriD· 2 shared Rupert C. L. BealeiD· 2 shared Andrea SerioiD· 1 shared Anne SchreiberiD· 1 shared Antoni G. WrobeliD· 1 shared Antonio Torres-MéndeziD· 1 shared Arvind H. PateliD· 1 shared Carmen Figueras-NovoaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Beatriz MontanerORCID

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2 papers

Recent·Most cited

SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis

Carmen Figueras-Novoa, Lewis Timimi, Elena Marcassa, Raquel Taveira‐Marques, Lorin Adams, Ming Jiang, Mary Wu, Beatriz Montaner, Kevin W. Ng, Giuditta De Lorenzo, Wilhelm Furnon, Vanessa M. Cowton, Nicole Upfold, George Kassiotis, Ruth Harvey, , Rupert C. L. Beale

This study shows SARS-CoV-2 E protein induces LC3 lipidation through the V-ATPase-ATG16L1 axis, which supports viral replication rather than inhibiting it.

bioRxiv · Jun 12, 2025 · PreprintCell Biology

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

Lewis Timimi, Antoni G. Wrobel, George N. Chiduza, Sarah Maslen, Antonio Torres-Méndez, Beatriz Montaner, Colin T. Davis, Taylor F. Minckley, Katriona L. Hole, Andrea Serio, Michael J. Devine, Mark J. Skehel, John L. Rubinstein, Anne Schreiber, Rupert C. L. Beale

This paper identifies the V1H subunit of V-ATPase as a regulator of ATG16L1 recruitment in response to pH gradient disruption, linking V-ATPase function to autophagy activation.

Molecular Cell · Jul 31, 2024Peer-reviewedMolecular Biology