Ming Jiang

Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis

This study shows SARS-CoV-2 E protein induces LC3 lipidation through the V-ATPase-ATG16L1 axis, which supports viral replication rather than inhibiting it.

Caspase cleavage of Influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production

This study shows that caspase cleavage of the Influenza A virus M2 protein disrupts its interaction with LC3, reducing virion production.

Actin and Src-family kinases regulate nuclear YAP1 and its export

This study identifies mechanisms regulating YAP1 nuclear shuttling in fibroblasts, showing that Src and actomyosin suppress YAP1 export, and nuclear export is central to YAP1 regulation.