Author

Gleb D. Rukhovich

German Cancer Research CenterORCID 0009-0004-7340-9357Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Elyas HeidariiD· 2 shared Moritz GerstungiD· 2 shared Oliver StegleiD· 2 shared Andrew R Moorman· 1 shared Anna MathioudakiiD· 1 shared Artem LomakiniD· 1 shared Dana Pe’eriD· 1 shared Dániel UnyiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Elyas HeidariORCID

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2 papers

Recent·Most cited

Integrated combinatorial functional genomics and spatial transcriptomics of tumors decodes genotype to phenotype relationships

Marco Breinig, Artem Lomakin, Elyas Heidari, Michael A. Ritter, Gleb D. Rukhovich, Lio Böse, Luise Butthof, Lena Wendler-Link, Hendrik Wiethoff, Tanja Poth, Felix Sahm, Peter Schirmacher, Oliver Stegle, Moritz Gerstung, Darjus Felix Tschaharganeh

The paper introduces CHOCOLAT-G2P, a method integrating functional genomics and spatial transcriptomics to study genotype-phenotype relationships in tumors, revealing zonation patterns and epistasis in liver cancer.

Nature Biomedical Engineering · Jul 28, 2025Peer-reviewedCancer Biology

Segger: Fast and accurate cell segmentation of imaging-based spatial transcriptomics data

Elyas Heidari, Andrew R Moorman, Dániel Unyi, Nikhita Pasnuri, Gleb D. Rukhovich, Domenico Calafato, Anna Mathioudaki, Joseph Minhow Chan, Tal Nawy, Moritz Gerstung, Dana Pe’er, Oliver Stegle

Segger improves cell segmentation in spatial transcriptomics by using a graph neural network, achieving high sensitivity and speed with minimal manual intervention.

bioRxiv · Mar 14, 2025 · PreprintBioinformatics