Author

Lio Böse

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Darjus Felix TschaharganehiD· 3 shared Hendrik WiethoffiD· 3 shared Marco BreinigiD· 3 shared Lena Wendler-Link· 2 shared Luise Butthof· 2 shared Peter SchirmacheriD· 2 shared Artem LomakiniD· 1 shared Aryan KamaliD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

Darjus Felix TschaharganehORCID

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3 papers

Recent·Most cited

Repurposing passenger amplifications as Trojan horses identifies MPZL1 as a potent target for solid cancers

Sonia Jiménez Vázquez, Christos Patsis, Mara Mitstorfer, Melanie Grimm, Luise Butthof, Lena Wendler-Link, Lio Böse, Hendrik Wiethoff, Ilse Hofmann, Kai Breuhahn, Thomas Longerich, Matthias M. Gaida, Peter Schirmacher, Judith Feucht, Marco Breinig, Darjus Felix Tschaharganeh

The paper identifies MPZL1 as a therapeutic target in 1q-amplified solid cancers by repurposing passenger amplifications as Trojan horses for targeted therapy delivery.

bioRxiv · Sep 17, 2025 · PreprintCancer Biology

Integrated combinatorial functional genomics and spatial transcriptomics of tumors decodes genotype to phenotype relationships

Marco Breinig, Artem Lomakin, Elyas Heidari, Michael A. Ritter, Gleb D. Rukhovich, Lio Böse, Luise Butthof, Lena Wendler-Link, Hendrik Wiethoff, Tanja Poth, Felix Sahm, Peter Schirmacher, Oliver Stegle, Moritz Gerstung, Darjus Felix Tschaharganeh

The paper introduces CHOCOLAT-G2P, a method integrating functional genomics and spatial transcriptomics to study genotype-phenotype relationships in tumors, revealing zonation patterns and epistasis in liver cancer.

Nature Biomedical Engineering · Jul 28, 2025Peer-reviewedCancer Biology

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

Bryce Lim, Aryan Kamal, Borja Gomez Ramos, Juan M. Adrian-Segarra, Ignacio L. Ibarra, Lennart Dignas, Tim Kindinger, Kai Volz, Mohammad Rahbari, Nuh N. Rahbari, Eric Poisel, Kanela Kafetzopoulou, Lio Böse, Marco Breinig, Danijela Heide, , Moritz Mall

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.

Nature Genetics · Feb 13, 2025Peer-reviewedCancer Biology