Hendrik Wiethoff

MechanoMaST - a multimodal pipeline for spatially registering mechanical and transcriptomic tissue data

MechanoMaST integrates mechanical and transcriptomic data from tissue samples to enable spatial correlation with high accuracy, revealing a stiffness-related gene signature in colorectal cancer.

Repurposing passenger amplifications as Trojan horses identifies MPZL1 as a potent target for solid cancers

The paper identifies MPZL1 as a therapeutic target in 1q-amplified solid cancers by repurposing passenger amplifications as Trojan horses for targeted therapy delivery.

Integrated combinatorial functional genomics and spatial transcriptomics of tumors decodes genotype to phenotype relationships

The paper introduces CHOCOLAT-G2P, a method integrating functional genomics and spatial transcriptomics to study genotype-phenotype relationships in tumors, revealing zonation patterns and epistasis in liver cancer.

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.