Aakash Chandramouli

The Hunt for Cholesteryl Ester Hydrolases: Identification of Lipoprotein Lipase as a Cholesterylesterase

This study identifies lipoprotein lipase (LPL) as a neutral cholesteryl ester hydrolase in mammals through biochemical and pharmacological analyses.

Orthogonal Chemical Proteomic Strategies Reveal the Cholesteryl Ester Interactome in Mammalian Cells

This study uses three orthogonal chemical proteomic strategies to identify 495 cholesteryl ester-associated proteins in mammalian cells, revealing their functional and disease relevance.

Lysine specific demethylase 1 (LSD1) regulates host alpha-ketoglutarate levels to modulate lipid peroxidation during Mycobacterium tuberculosis infection

This study shows LSD1 regulates host alpha-ketoglutarate levels, modulating lipid peroxidation and mycobacterial survival during tuberculosis infection.

A metabolic hierarchy directs cell cycle transition and morphogenesis

This study identifies a metabolic hierarchy in Caulobacter crescentus that coordinates cell cycle transitions and morphogenesis through redox dynamics.

Integrative lipidomics of brain and plasma uncovers sex-specific metabolic signatures in Parkinson's disease

The paper identifies shared and sex-specific lipidomic changes in brain and plasma of Parkinson's disease models and patients, showing peripheral lipid signatures reflect CNS pathology.

PE11 promotes intracellular persistence of Mycobacterium tuberculosis by inhibiting autophagy and lysosomal biogenesis by targeting the FLCN-lactate-TFEB signaling axis

This study identifies PE11 as a factor that promotes Mtb persistence by inhibiting autophagy and lysosomal biogenesis through the FLCN-lactate-TFEB signaling axis, with lactate shown to enhance bacterial clearance.