Author

Xinyin Wang

University of TorontoORCID 0009-0004-9053-458XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Jeffrey E. LeeiD· 2 shared Alexander SchleifferiD· 1 shared Andrea PauliiD· 1 shared Andreas BlahaiD· 1 shared Clara S. Phan· 1 shared Dominik HandleriD· 1 shared Elisabeth RoitingeriD· 1 shared Emilio GómeziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Jeffrey E. LeeORCID

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2 papers

Recent·Most cited

JUNO-Coated Beads as a Functional Assay to Capture and Characterize Fertilization-Competent Human Sperm

Paula Cots, Xinyin Wang, Mirian Sanchez-Tudela, K.K.W. Siu, Patrick Yip, Emilio Gómez, Jeffrey E. Lee, Julieta Gabriela Hamze, María Jiménez‐Movilla

This paper develops a JUNO-coated bead assay to capture and characterize fertilization-competent human sperm, showing that vitrification preserves functional binding while slow freezing increases non-specific interactions.

Human Reproduction Open · Jan 1, 2026Peer-reviewedCell Biology

A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates

Victoria E. Deneke, Andreas Blaha, Yonggang Lu, Johannes P Suwita, Jonne M. Draper, Clara S. Phan, Karin Panser, Alexander Schleiffer, Laurine Jacob, Theresa Humer, Karel Stejskal, Gabriela Krššáková, Elisabeth Roitinger, Dominik Handler, Maki Kamoshita, , Andrea Pauli

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

Cell · Oct 17, 2024Peer-reviewedDevelopmental Biology