EZH2 Inhibition Induces a Metabolic Stress Response Sensitizing TNBC to Glutaminase Targeting
Lucas Porras, Marina Fukano, Ann-Sophie Gironne, Elise Quadri, Gabriel Alzial, Hugo Philippeau, Yousef Aleassa, Anie Monast, Faustine Gorse, Myriame Saint-Arnaud, Mariana De Sa Tavares Russo, Sylvie Mader, Daina Zofija Avizonis, Sébastien Lemieux, Morag Park, Geneviève Deblois
This study shows that EZH2 inhibition in TNBC causes metabolic stress, making cells more sensitive to glutaminase inhibitors.
bioRxiv · Sep 4, 2025 · PreprintCancer Biology