Gyan Ranjan

This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.

This paper shows NFAT2 regulates Orai3 expression differently in non-metastatic and metastatic cancer cells through transcriptional activation and MARCH8-mediated degradation, linked to MARCH8 promoter methylation.

This paper identifies Orai3 as a driver of gemcitabine resistance in pancreatic cancer through the Orai3-NFATc1-SLIT3 signaling pathway, showing its role in cell proliferation, apoptosis, and metastasis.

This study investigates syntenic lncRNAs across humans and zebrafish, finding they exhibit regulatory functions through DNA elements despite limited sequence conservation.

This paper identifies and functionally validates the scar-6 lncRNA locus, showing it regulates prozb expression and modulates coagulation and vascular function in zebrafish through epigenetic mechanisms.

This study identifies TAAL, a lncRNA that modulates Tie1 signaling and vascular function in diabetic retinopathy, showing its role in endothelial cell behavior and potential therapeutic relevance.

FELUDA uses FnCas9 for rapid, accurate nucleobase detection and is implemented in a point-of-care diagnostic tool for SARS-CoV-2.

The paper analyzes SARS-CoV-2 isolates from Kerala, India, identifying 166 unique variants, including 4 novel ones, and reports on their genetic epidemiology and potential impact on diagnostics.

This study evaluates the COVIDSeq protocol for SARS-CoV-2 detection and genetic epidemiology, showing high concordance with RT-PCR and identifying novel variants and lineages.

This study sequenced SARS-CoV-2 genomes from Andhra Pradesh, identifying 564 variants including 15 novel ones and 4 associated with increased infectivity.

The paper investigates the genetic epidemiology of immune escape variants in SARS-CoV-2 genomes globally.