Shota Y. Yoshida

Genome-wide epitope identification with single-amino-acid resolution via high-throughput and unbiased peptide analysis

This study introduces DECODE, a high-throughput method for identifying epitopes at single amino acid resolution, demonstrating its utility in antibody-based research and disease modeling.

Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.

Realization of phosphorylation hypothesis of sleep by mammalian CaMKIIβ

This study shows that CaMKIIβ phosphorylation regulates sleep duration and steps in mammals by modulating kinase activity in excitatory neurons.