Nathan X. Chai

This study investigates how trisomy 21 affects oligodendrocyte development and neuron-glia communication in human forebrain assembloids, finding a shift toward a pre-myelinating state and disrupted myelination.

Four miniature lenses sharing one CMOS sensor, with computational stitching, give cellular-resolution imaging over 7.5 × 10 mm^2 at video rate, resolving 3,474 mouse cortical neurons.

This study shows that visual gamma stimulation increases low-frequency blood flow oscillations in multiple cortical regions of mice, with effects lasting beyond 24 hours.

The paper shows that hemodynamic responses in the cortex are influenced by neuromodulators like norepinephrine, with distinct impulse response functions for different neuromodulatory signals.