Sreekanth Kura

High-Density Multi-Distance fNIRS Enhances Detection of Brain Activity during a Word-Color Stroop Task

This study compares high-density and sparse fNIRS arrays in detecting brain activity during a Word-Color Stroop task, finding HD arrays provide better localization and sensitivity in image space.

Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis

This study shows carbonic anhydrase inhibitors prevent capillary flow issues in a mouse model of early Alzheimer's disease before symptoms appear.

Neurovascular Impulse Response Function (IRF) during spontaneous activity differentially reflects intrinsic neuromodulation across cortical regions

The paper shows that hemodynamic responses in the cortex are influenced by neuromodulators like norepinephrine, with distinct impulse response functions for different neuromodulatory signals.

Widefield in vivo imaging system with two fluorescence and two reflectance channels, a single sCMOS detector, and shielded illumination

The paper describes a widefield in vivo imaging system for mesoscopic brain imaging, capable of capturing fluorescent and reflectance signals, and demonstrates its use in awake mice.

ninjaCap: A fully customizable and 3D printable headgear for fNIRS and EEG brain imaging

The paper introduces ninjaCap, a 3D printable headgear system for fNIRS and EEG that improves sensor placement accuracy and reduces manual labor.

High Throughput Detection of Capillary Stalling Events with Bessel Beam Two-Photon Microscopy

This study develops a Bessel beam two-photon microscope to detect capillary stalling events in stroke models, showing increased stalling beyond the acute phase.

Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

This paper quantifies myelin content and neuron density in the human brain using OCT, finding a strong linear relationship between scattering coefficient and myelin content.

Anatomical modeling of brain vasculature in two-photon microscopy by generalizable deep learning

This paper develops a deep learning method for segmenting brain vasculature from two-photon microscopy images, achieving faster computation and better generalization across imaging systems.

Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice

This study shows that subarachnoid hemorrhage in mice causes early and lasting changes in functional connectivity and cognitive performance.

Rapid disruption of the cortical microcirculation after mild traumatic brain injury

This study shows that mild traumatic brain injury rapidly disrupts cortical microcirculation, causing severe reductions in cerebral blood flow and vascular dysfunction.

Neutrophil-mediated dynamic capillary stalls in ischemic penumbra: persistent traffic jams after reperfusion contribute to injury

The paper identifies dynamic capillary flow stalls in mice after stroke reperfusion, mediated by neutrophils, which impair circulation and contribute to penumbral injury.

Homogenization of capillary flow and oxygenation in deeper cortical layers correlates with increased oxygen extraction

The paper measures capillary flow and oxygenation in cortical layers of awake mice, finding homogenization of oxygen delivery and increased extraction in layer IV.