A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway
Delphine Bonhomme, Hugo Vaysset, Eirene Marie Q. Ednacot…·Enzo Z. Poirier
The paper identifies SIRanc, a human homolog of bacterial antiphage SIR2 proteins, and shows it mediates innate immunity via the TLR pathway by degrading NAD+.