This study identifies Sox2 as a regulator of lateral line morphogenesis in zebrafish by modulating Yap/Taz-mediated mechanotransduction and cell proliferation.

bioRxiv · Sep 18, 2025 · PreprintDevelopmental Biology

A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway

Delphine Bonhomme, Hugo Vaysset, Eirene Marie Q. Ednacot, Vasco Rodrigues, Yazan Salloum, Jean Cury, Anny Wang, Axel Benchetrit, Pierre Affaticati, Veronica Hernandez Trejo, Paul Vittot, Charlie Bories, Alexis Cornec, Jean‐Pierre Levraud, Pedro P. Hernández, , Enzo Z. Poirier

The paper identifies SIRanc, a human homolog of bacterial antiphage SIR2 proteins, and shows it mediates innate immunity via the TLR pathway by degrading NAD+.

Science · Jul 24, 2025Peer-reviewedImmunology

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition

Yazan Salloum, Gwendoline Gros, Keinis Quintero-Castillo, Camila Garcia-Baudino, Soraya Rabahi, Akshai Janardhana Kurup, Patricia Diabangouaya, David Pérez-Pascual, Rodrigo A Morales, Jos Boekhorst, Eduardo J. Villablanca, Jean‐Marc Ghigo, Carmen Gloria Feijóo, Sylvia Brugman, Pedro P. Hernández

This study shows IL-26 from innate lymphoid cells regulates gut epithelial homeostasis by shaping microbiota composition in zebrafish larvae.

bioRxiv · May 5, 2025 · PreprintImmunology

Interleukin-22 in enteroendocrine cells controls early-life gut motility through interactions with the microbiota

Soraya Rabahi, Emiliano Marachlian, Fabian Guendel, Aya Mikdache, Keinis Quintero-Castillo, Lucie Maurin, Vincenzo Di Donato, Akshai Janardhana Kurup, Yazan Salloum, Gwendoline Gros, Patricia Diabangouaya, Camila Garcia-Baudino, Ignacio Medina-Yáñez, Jean‐Pierre Levraud, Georges Lutfalla, , Pedro P. Hernández

This study shows that IL-22 from enteroendocrine cells in zebrafish larvae controls gut microbiota and motility, with similar effects observed in mice.

bioRxiv · Apr 25, 2025 · PreprintImmunology

A non-invasive photoactivatable split-Cre recombinase system for genome engineering in zebrafish.

Ramy Elsaid, Aya Mikdache, Patricia Diabangouaya, Gwendoline Gros, Pedro P. Hernández

This paper develops a non-invasive light-inducible split-Cre system for precise genome engineering in zebrafish.

bioRxiv · Jun 23, 2023 · PreprintDevelopmental Biology

Sox2 and Sox3 are essential for development and regeneration of the zebrafish lateral line

Cristian Alberto Undurraga, Yunzi Gou, Pablo C. Sandoval, Viviana A Nuñez, Miguel L. Allende, Bruce B. Riley, Pedro P. Hernández, Andrés F. Sarrazin

The paper identifies Sox2 and Sox3 as essential for lateral line development and regeneration in zebrafish by characterizing stem cells and their regenerative capabilities.

bioRxiv · Nov 26, 2019 · PreprintDevelopmental Biology