Shibo Hou

This study evaluates CRISPR-based homing gene drives targeting female fertility genes in Drosophila to suppress population growth, finding varying efficiency and fitness costs across targets.

This paper introduces a two-target gene drive design that improves suppression efficiency by combining homing and fitness cost elements, showing success in Drosophila but highlighting remaining challenges.

This paper demonstrates the feasibility of using CRISPR-Cas9 gene drives in the medfly to achieve sex conversion and female sterility, offering a strategy for pest population suppression.

This paper describes a homing gene drive targeting the hairy gene in insects, which spreads to high frequency in cage populations but generates functional resistance alleles despite using multiple gRNAs.