Author

Sergio Helgueta

University of LiègeORCID 0000-0002-4100-2964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Alessia SciortinoiD· 2 shared Ira Espuny-CamachoiD· 2 shared Lasse SinkkoneniD· 2 shared Manuel ButtiniiD· 2 shared Michel Guy André MittelbronniD· 2 shared Pierre GarciaiD· 2 shared Rashi HalderiD· 2 shared Alessia CambieriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Alessia SciortinoORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Organoid-to-organoid transplantation and pro-neurogenic treatment promote graft integration and neuronal repair in a human ischemic model

Ricardo Gómez‐Oliva, Sergio Helgueta, Nerea Alonso-Galeron, Alessia Cambier, Fatemeh Ghanavatinejad, Gérald Masset, Lisa Collin, Pedro Nunez‐Abades, Rosario Hernández‐Galán, Carmen Castro, Ira Espuny-Camacho

This study shows that combining organoid transplantation with pro-neurogenic treatment improves graft integration and neuronal repair in a human ischemic model.

bioRxiv · Oct 1, 2026 · PreprintNeuroscience

Untangling mechanisms for cerebellar neural specification using human pluripotent stem cell-derived organoids

Sergio Helgueta, Antonela Bonafina, Nicolas Olivié, Bernard Coumans, Laurent Nguyen, Ira Espuny-Camacho

This study uses human pluripotent stem cell-derived cerebellar organoids to investigate human cerebellar development and disease-related gene expression.

bioRxiv · Apr 29, 2026 · PreprintNeuroscience

Transcriptional Dysregulation in the Hippocampus of a murine model for Parkinson's Disease Cognition Impairment is Driven by Sex, Age, and Alpha-synuclein overexpression

Alessia Sciortino, Thomas Hentrich, Sergio Helgueta, Pierre Garcia, Kristopher J. Schmit, Mélanie H. Thomas, Rashi Halder, Djalil Coowar, Michel Guy André Mittelbronn, Lasse Sinkkonen, Julia Maria Schulze-Hentrich, Manuel Buttini

bioRxiv · Jul 18, 2025 · PreprintNeuroscience

Park7 deletion leads to age- and sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes

Sergio Helgueta, Tony Heurtaux, Alessia Sciortino, Yujuan Gui, Jochen Ohnmacht, Pauline Mencke, Ibrahim Boussaad, Rashi Halder, Pierre Garcia, Rejko Krüger, Michel Guy André Mittelbronn, Manuel Buttini, Thomas Sauter, Lasse Sinkkonen

The paper shows that Park7 deletion causes sex-specific transcriptome changes in male mouse midbrain astrocytes via the NRF2-CYP1B1 axis, affecting oxidative stress and EMT processes.

bioRxiv · Feb 23, 2024 · PreprintMolecular Biology