Author

Hannah Osterholz

Uppsala UniversityORCID 0009-0006-3481-1540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Axel LeppertiD· 3 shared Cecilia MörmaniD· 3 shared Michael LandrehiD· 3 shared Axel AbeleiniD· 2 shared Dilraj LamaiD· 2 shared Ali MisereziD· 1 shared Anna RisingiD· 1 shared Carmine Pasquale CerratoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

Axel LeppertORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintJul 27, 2026

Single-molecule mass measurements uncover shifting RNA interactions during condensate phase transitions

Axel Leppert, Jesper Shiapan, Irena Papageorgiou…·Michael Landreh

The paper uses mass photometry to study RNA-protein interactions in phase-separated systems, showing RNA promotes tau multimerization and phase re-entry.

DOI 10.64898/2026.07.27.740926

protein structureexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintMar 6, 2026

Liquid-liquid phase separation of tau regulates client binding via a conformational relay

Hannah Osterholz, Gefei Chen, Jakob Freudenberger…·Axel Leppert

The paper investigates how tau's liquid-liquid phase separation affects its binding to BRICHOS and tubulin, showing conformational changes regulate these interactions.

DOI 10.64898/2026.01.21.700558

humanproteomics

𝕏 PostBluesky

BiophysicsJournal of the American Chemical SocietyPeer-reviewedJul 4, 2024

Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions.

Axel Leppert, Jianhui Feng, Vaida Railaite…·Michael Landreh

This paper demonstrates laser-induced control of sol-gel transitions in protein condensates to enable drug loading.

20 citations

proteomicsimaging

𝕏 PostBluesky