Michael Landreh

Single-molecule mass measurements uncover shifting RNA interactions during condensate phase transitions

The paper uses mass photometry to study RNA-protein interactions in phase-separated systems, showing RNA promotes tau multimerization and phase re-entry.

Native mass spectrometry of membrane protein lipid and ligand complexes using de novo designed WRAP domains

The paper demonstrates that WRAP domains designed with deep learning can preserve weak interactions of membrane protein complexes in native mass spectrometry, enabling characterization of lipid and ligand interactions without detergent micelles.

A systematic approach to understanding how patient variants affect the activity of Wiskott-Aldrich syndrome protein

This paper systematically analyzes how patient variants affect WASp activity, identifying gain-of-function and loss-of-function variants through structural and functional assays.

Liquid-liquid phase separation of tau regulates client binding via a conformational relay

The paper investigates how tau's liquid-liquid phase separation affects its binding to BRICHOS and tubulin, showing conformational changes regulate these interactions.

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

AI-first structural identification of pathogenic protein targets

The paper predicts structures of human-pathogen protein interactions using AlphaFold, finding 30 high-quality models and confirming a novel heterotetrameric complex with potential immune evasion implications.

Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions.

This paper demonstrates laser-induced control of sol-gel transitions in protein condensates to enable drug loading.