Author

Ye-Eun Yoo

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jingliang ZhangiD· 4 shared Yang YangiD· 4 shared Brody A. DemingiD· 3 shared Chongli YuaniD· 3 shared Kyle W. WettschurackiD· 3 shared Manasi Suchit HalurkariD· 3 shared Morgan J. RobinsoniD· 3 shared Nadia A. LanmaniD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Jingliang ZhangORCID

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Author profile →

4 papers

Recent·Most cited

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids

Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, Morgan J. Robinson, Harish Kothandaraman, Ye-Eun Yoo, Iria G. Dopeso‐Reyes, Thomas D Buffenoir, Manasi Suchit Halurkar, Hui Yang, Zaiyang Zhang, Muhan Wang, Erin N Creager, Harris D. Giles, Yuanrui Zhao, , Yang Yang

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

Neuron · Sep 1, 2026Peer-reviewedNeuroscience

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a-deficient mice

Ye-Eun Yoo, Zaiyang Zhang, Purba Mandal, Zhengkuan Tang, Jingliang Zhang, Xiaoling Chen, Morgan J. Robinson, Muriel Eaton, Brody A. Deming, Manasi Suchit Halurkar, Harish Kothandaraman, Luke Child Dabin, Boyu Jiang, Hongyu Gao, Chongli Yuan, , Yang Yang

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

Translational Psychiatry · Jul 31, 2026Peer-reviewedNeuroscience

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation

Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle W. Wettschurack, Morgan J. Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A. Deming, Akila D. Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C. Skarnes, , Yang Yang

This study uses brain organoids and assembloids with microglia to show region-specific microglial diversity and their response to SCN2A mutation-induced neuronal hyperactivity.

bioRxiv · Jun 4, 2025 · PreprintNeuroscience

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency

Jingliang Zhang, Muriel Eaton, Xiaoling Chen, Yuanrui Zhao, Shivam Kant, Brody A. Deming, Kothandaraman Harish, Huynhvi P. Nguyen, Yue Long Shu, Shirong Lai, Jiaxiang Wu, Zhefu Que, Kyle W. Wettschurack, Zaiyang Zhang, Tiange Xiao, , Yang Yang

This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.

bioRxiv · Mar 4, 2025 · PreprintNeuroscience