Author

Robert E. Hughes

ORCID 0009-0006-5650-2802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

Aditi DeshpandeiD· 2 shared Assem DuisembekovaiD· 2 shared Bénédicte F. PyiD· 2 shared Dominic FerberiD· 2 shared George D. HartmaniD· 2 shared Hannes ButhmanniD· 2 shared Inga V. HochheiseriD· 2 shared Jane TorpiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Aditi DeshpandeORCID

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2 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedJul 24, 2025

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

Kevin Wilhelmsen, Aditi Deshpande, Sarah U. Tronnes…·Rebecca C. Coll

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

21 citationstop 2%

humanmouse

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ImmunologybioRxivPreprintJul 1, 2025

Inhibition of NLRP3 by a CNS-penetrating indazole scaffold

Jane Torp, Dominic Ferber, Hannes Buthmann…·Matthias Geyer

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

4 citations

mouseexperimental assay

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