Author

Carina R. Sclafani

University of PittsburghORCID 0009-0006-6792-7953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Christopher J. BakkenistiD· 2 shared Frank P. VendettiiD· 2 shared Pinakin PandyaiD· 2 shared Ava Clump· 1 shared Bennett Van HouteniD· 1 shared Daniel IvanoviD· 1 shared Greg M. DelgoffeiD· 1 shared Jan Hendrik BeumeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Christopher J. BakkenistORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 26, 2026

ATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo

Frank P. Vendetti, Carina R. Sclafani, Yunqi Zhang…·Christopher J. Bakkenist

This study shows ATR kinase inhibitors cause mitochondrial fission and impair immune memory in CD8+ T cells during viral infection.

DOI 10.64898/2026.05.25.727628

mouseexperimental assay

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Cancer BiologyNAR CancerPeer-reviewedOct 7, 2025

Uracil-DNA glycosylase deficiency is associated with repressed tumor cell-intrinsic inflammatory signaling and altered sensitivity to exogenous interferons

Frank P. Vendetti, Pinakin Pandya, Carina R. Sclafani…·Christopher J. Bakkenist

This study shows that UNG deficiency in tumor cells reduces intrinsic inflammatory signaling and alters interferon sensitivity, leading to a modified tumor microenvironment.

2 citations

mousebulk RNA-seq

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