Zilu Ye

This study identifies BNIP3L/NIX-mediated mitophagy as a critical pathway that limits Alzheimer's disease pathology and preserves neuronal function by maintaining mitochondrial health and reducing proteotoxicity.

The paper introduces an integrated workflow for high-throughput single-cell proteomics, achieving high throughput and protein identification using SPRINT and dual-spray LC-MS.

This study introduces MAP-MS, a method to improve proteomic dynamic range using Orbitrap mass spectrometers without hardware or software changes, achieving nearly 2x dynamic range with minimal impact.

This study introduces SC-pSILAC, a method to measure protein abundance and turnover in single cells, revealing differentiation-specific dynamics and cell-type markers in human iPSCs.

This study improves single-cell proteomics by increasing protein identification from ~2000 to over 5000 per cell and enhancing throughput and reliability.

The paper uses spatiotemporal proteomics to identify how different EGFR ligands induce distinct signaling outcomes, revealing key proteins and phosphorylation sites involved in endocytic fate and functional selectivity.

The paper introduces Narrow-window DIA, a fast proteomics method enabling high-throughput and comprehensive proteome analysis with high precision and accuracy.