Ali Shaib

This study investigates how synapsin-1 and actin form ordered nanoscale assemblies through phase separation, showing that actin scaffolds retain structural memory for condensate reformation.

The paper introduces Mega-expansion microscopy, a fluorescence imaging technique that enables high-resolution structural visualization of whole cells using conventional microscopes.

A four-network sodium acrylate/dimethylacrylamide hydrogel, cast ionic-within-ionic without neutral re-embedding, reaches about 1000-fold linear expansion and resolves individual peptide residues on standard confocal microscopes.

This paper introduces a single-step expansion microscopy method enabling SMLM with spontaneously blinking dyes in expanded samples, achieving nanometer-resolution imaging of cellular structures.

This study overexpresses human alpha-synuclein in rodent glutamatergic neurons and finds no significant impairment in synaptic function.

The paper develops an optimized Ex-dSTORM method to resolve endogenous protein assemblies with nanometer precision in cells.

The paper introduces IVEA, a deep-learning platform for automated exocytosis analysis in live-cell imaging, which is faster and more reliable than manual methods.

The paper introduces MJF-14 PLA, a proximity ligation assay for detecting non-inclusion alpha-synuclein aggregates with high specificity and sensitivity, showing pathology precedes Lewy body formation in Parkinson's disease.

This study uses a fluorescent nanosensor paint to show that dopamine release from individual varicosities is highly heterogeneous and requires molecular priming.