Kavitha Sarma

Socially regulated genes are spatially hyperconnected to enhancers in the ant brain

The paper identifies socially regulated genes in ants that show increased 3D chromatin contacts with enhancers, suggesting pre-existing connectivity supports brain plasticity during caste transition.

Gastruloid patterning reflects division of labor among biased stem cell clones

The paper shows that stem cell clones in gastruloids exhibit spatial propensities for anterior/posterior fates, leading to spontaneous division of labor during axial organization.

Pooled scanning of protein variants identifies novel RNA-binding mutants

The paper introduces RBR-scan, a method to identify RNA-binding mutants by measuring affinity of protein variants, and validates it with known and novel mutants in SRSF2.

Innate Immune Memory is Stimulus Specific

This study shows that innate immune memory in macrophages is stimulus-specific, with distinct phenotypic and epigenetic responses depending on the initial training stimulus.

AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance

The paper shows melanoma cells develop therapy resistance through AP-1-mediated cellular memories that encode transient gene expression and chromatin changes.

BisMapR: a strand-specific, nuclease-based method for genome-wide R-loop detection

BisMapR is a strand-specific, nuclease-based method for genome-wide R-loop detection, revealing new features of active enhancers and promoter R-loop behavior.

Mapping native R-loops genome-wide using a targeted nuclease approach

The paper introduces a method to map R-loops genome-wide using a targeted nuclease approach, achieving high specificity, sensitivity, and low input requirements.