Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids
Thomas M. Rawlings, Komal Makwana, Deborah M. Taylor, Matteo A. Molè, Katherine J. Fishwick, Maria Tryfonos, Joshua Odendaal, Amelia Hawkes, Magdalena Zernicka‐Goetz, Geraldine M. Hartshorne, Jan Joris Brosens, Emma S. Lucas
Endometrial assembloids of gland organoids and stromal cells reproduce midluteal cell states by scRNA-seq. Senescent decidual cells, tuned with dasatinib, track with whether co-cultured human blastocysts expand or stall.
eLife · Sep 6, 2021Peer-reviewedDevelopmental Biology✦ In-depth digest