Kathryn Crouch

This study uses single-cell transcriptomics to analyze life cycle and cell cycle gene expression dynamics in two Leishmania species during in vitro growth, revealing developmental endpoints and cell cycle-related gene expression patterns.

paraCell provides an interactive tool for analyzing and visualizing host-parasite single-cell RNA-Seq data without requiring programming skills.

This study uses Nanopore sequencing to show that DNA replication compartmentalization in Trypanosoma brucei affects genome stability and instability by influencing VSG gene recombination and chromosome stability.

The paper identifies essential membrane transporters for Leishmania survival through a CRISPR-Cas9 gene deletion screen, finding that V-ATPase is critical for amastigote survival despite being dispensable for promastigote growth.

The paper introduces an updated version of the Companion web server for genome annotation, improving efficiency and expanding reference genomes to include fungi and arthropods.

The paper isolates and characterizes novel Clostridium XIVa strains from the murine gut, revealing genomic diversity driven by mobile genetic element acquisition and expanded biosynthetic potential.

This paper introduces CORRAL, a tool for detecting eukaryotes in metagenomic data, showing it can identify novel strains and integrate with web-based analysis tools.

peaks2utr annotates 3' UTRs using UTR enrichment from single-cell technologies to improve transcriptomic analysis.

This study shows that TbRH2A is essential for resolving R-loops and preventing DNA damage in T. brucei, with distinct roles in RNA Pol II and Pol I transcription.

The paper maps R-loop activities across the genome of Trypanosoma brucei, revealing conserved and novel roles in transcription and genome dynamics.

This study shows that ATR kinase in Trypanosoma brucei is essential for DNA damage signaling and controls monoallelic VSG expression during antigenic variation.

This study identifies PfCLK3 as a druggable target for malaria by showing its essential role in multiple parasite life stages across species.