Qing Nie

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

This paper introduces iSORT, a transfer learning method that integrates single-cell and spatial transcriptomics data to reconstruct spatial organization and identify key genes in multicellular systems.

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

The paper analyzes inter-cellular communication changes in Alzheimer's Disease using snRNA-seq and CellChat, finding conserved glutamatergic transmission changes in mice and humans.