Anne Czechanski

The study examines how genetic variation in mouse induced pluripotent stem cells affects gene expression and cell cycle responses to triphenyl phosphate exposure.

The paper identifies that X chromosome dosage influences aneuploidy development in mouse embryonic stem cells, with XO and XY lines showing higher aneuploidy rates than XX lines.

The paper generates a genetically diverse panel of iPSCs from a mouse population and identifies regulatory loci influencing gene expression variation.

This study identifies a shared genetic regulator linking metabolism and addiction-related behavior in mice and humans through a common enhancer regulating Eed/Me3 and EED/ME3.

The paper presents a mouse pangenome with 17 strains, resolving structural complexity and improving RNA-Seq analysis by identifying non-reference genes and VNTR polymorphisms.

This study identifies Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression by analyzing mouse strain differences and cell line models.

The paper presents T2T mouse genomes for C57BL/6J and CAST/EiJ, revealing structural diversity in telomeres, centromeres, and key loci like PAR and KZFPs.

This paper establishes a pluripotent stem cell platform using genetically diverse mouse lines to study the impact of natural genetic variation on development and gene regulation.

The paper uses regression modeling to identify genetic-epigenetic interactions in mice, showing they are common and structured by 3D chromatin domains.

The paper identifies structural variants in 20 mouse strains using long-read sequencing, revealing transposable elements' role in chromatin remodeling and gene expression in mESCs.

This study shows that lesion environments direct transplanted neural progenitors to differentiate into neuroprotective astroglial cells in CNS injuries.

The paper shows genetic variation in mouse ESCs affects lineage commitment by modulating pluripotency epigenome regulators, with B6 and D2 strains showing distinct differentiation biases.

This study shows that Xlr3 deficiency disrupts DDR factor recruitment to the XY body, leading to MSCI breakdown and spermatogenic defects in mice.

The paper identifies genetic variants influencing metastability in mouse embryonic stem cells by analyzing gene expression and chromatin accessibility in 185 genetically diverse cells.

The paper presents full-length de novo genome assemblies for 16 inbred mouse strains, identifying strain-specific haplotypes and novel functional loci, including a large unannotated gene with potential developmental roles.