Author

Mélanie Messmer

Centre National de la Recherche ScientifiqueORCID 0009-0007-9003-2995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Sébastien PfefferiD· 3 shared Béatrice Chane-Woon-Ming· 2 shared Erika GirardiiD· 2 shared Ali FendriiD· 1 shared Amélie Weiss· 1 shared Arnaud Kopp· 1 shared Bryan C. MounceiD· 1 shared Charline PasquieriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMolecular Biology

Sébastien PfefferORCID

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3 papers

Recent·Most cited

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response

Charline Pasquier, Mélanie Messmer, Lise Moroge, Lisanne I Knol, Johana Chicher, Richard Patryk Ngondo, Sébastien Pfeffer, Erika Girardi

This study shows FASN depletion increases cytoplasmic endogenous dsRNA and enhances antiviral innate immune responses.

bioRxiv · Jul 16, 2025 · PreprintImmunology

Non-canonical contribution of human Dicer helicase domain in antiviral innate immune response

Morgane Baldaccini, Léa Gaucherand, Béatrice Chane-Woon-Ming, Mélanie Messmer, Floriane Gucciardi, Sébastien Pfeffer

The paper investigates the role of Dicer's helicase domain in antiviral immunity, finding that a truncated mutant acts RNAi-independently via PKR and NF-kB pathways.

The EMBO Journal · Jan 29, 2024Peer-reviewedMolecular Biology

High-throughput fluorescence-based screen identifies the neuronal microRNA miR-124 as a positive regulator of alphavirus infection

Paula López, Erika Girardi, Bryan C. Mounce, Amélie Weiss, Béatrice Chane-Woon-Ming, Mélanie Messmer, Pasi Kaukinen, Arnaud Kopp, Diane Bortolamiol-Bécet, Ali Fendri, Marco Vignuzzi, Laurent Brino, Sébastien Pfeffer

The paper identifies miR-124 as a positive regulator of alphavirus infection through a genome-wide miRNA screen and shows its direct interaction with viral RNA.

Journal of Virology · Feb 21, 2020Peer-reviewedMolecular Biology