George Nolan

This study develops mRNA-LNP therapy for MNGIE, restoring nucleoside balance and TP expression in mice through subcutaneous delivery.

This study uses SiMPull to detect nanoscopic tau aggregates in PD brain regions, finding high-intensity aggregates in some PD cases despite negative IHC results.

The paper shows TNFα promotes tau aggregation at pre-synapses in human neurons, forming non-fibrillar aggregates that replicate rapidly.

The paper examines tau aggregates in Alzheimer's disease synaptosomes, finding that small tau aggregates are associated with early synaptic pathology.