Author
University of California, San FranciscoORCID 0000-0001-9970-016XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Serena Tamura, Andrew D. Nelson, Perry W.E. Spratt…·Kevin J. Bender
This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.
Chenyu Wang, Kimberly D. Derderian, Elizabeth C. Hamada…·Kevin J. Bender
The paper identifies impaired cerebellar plasticity as a mechanism underlying hypersensitized sensory reflexes in SCN2A-associated ASD, showing that increasing Scn2a expression rescues VOR plasticity in mice.
Andrew D. Nelson, Amanda M. Catalfio, Julie P. Gupta…·Paul M. Jenkins
This study shows that Ank2 and Scn2a work together in dendrites of neocortical neurons, linking their dysfunction to autism spectrum disorder.
Perry W.E. Spratt, Ryan P.D. Alexander, Roy Ben‐Shalom…·Kevin J. Bender
The paper shows that loss of NaV1.2 sodium channels in pyramidal neurons leads to hyperexcitability and seizures despite reduced action potential size and speed.
Roy Ben‐Shalom, J. T. Balewski, Anand Siththaranjan…·Kristofer E. Bouchard
This paper uses CNNs to infer neuronal ionic conductances from simulated membrane potentials, achieving better accuracy than traditional optimization methods.