Target-Stabilized Base Editors Enable Robust High-Fidelity RNA Editing
Taian Liu, Yunping Lin, Qiwei Liu, Wenhui Liao, Yunyi Lin, Yujing Zhang, Jianqing Zhang, Wenhua Cao, Lixin Yang, Zexuan Hong, Zhonghua Lu
This paper introduces RECODE, a system that improves RNA editing specificity by using gRNA-regulated ADAR1 deaminase stability, achieving high editing efficiency for a FUS mutation.
Nature Communications · Feb 25, 2026Peer-reviewedMolecular Biology