Prime editing primarily induces undesired outcomes in mice
Tomomi Aida, Jonathan J. Wilde, Lixin Yang, Yuanyuan Hou, Mengqi Li, Dongdong Xu, Jianbang Lin, Peimin Qi, Zhonghua Lu, Guoping Feng
In mouse zygotes, prime editing installed 10 modifications across 6 genes, but undesired products such as large deletions outnumbered intended edits, traced to PE3 double-nicking.
bioRxiv · Aug 6, 2020 · PreprintMolecular Biology