Simon J. Hubbard

The yeast Gcn2 protein kinase mediates P-body formation both through its activity with eIF2α and with non-canonical substrates

This study shows that yeast Gcn2 promotes P-body formation through eIF2α phosphorylation and Smu2-dependent mRNA granule maturation, even when eIF2α phosphorylation is blocked.

Implementing the re-use of public DIA proteomics datasets: from the PRIDE database to Expression Atlas

The paper introduces a pipeline to re-analyze public DIA proteomics datasets, integrating results into Expression Atlas to enhance data availability and utility.

Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

The paper develops a whole-cell metabolic model for yeast to predict compartment-specific proteome constraints that explain metabolic strategies under different growth conditions.

MRSD: a novel quantitative approach for assessing suitability of RNA-seq in the clinical investigation of mis-splicing in Mendelian disease

The paper introduces MRSD, a metric to determine optimal RNA-seq depth and tissue for assessing splicing variants in Mendelian diseases, showing LCLs are best for most gene panels.

Functional analysis of caspase cleavable proteoforms from the Drosophila GSK-3 gene shaggy.

This study investigates caspase cleavage of Drosophila Sgg-PD proteoforms, revealing their role in cytoskeletal and cell junction regulation and unexpected retention of cleaved N-terminal domains.

Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy

The paper characterizes protein isoforms of the Drosophila sgg gene, revealing distinct localization, interactions, and functions for different proteoforms during development.