Author

Brandon A. Keith

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Rachel J. HardingiD· 3 shared A.M. EdwardsiD· 2 shared Derek J. WilsoniD· 2 shared Esther WolfiD· 2 shared Hiroaki SugaiD· 2 shared Matthew G. AlteeniD· 2 shared Rebeka Cataldo de Oliveira FantiiD· 2 shared Renu ChandrasekaraniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Rachel J. HardingORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Macrocyclic Peptide Tools for Huntingtin-bound HAP40

Esther Wolf, Rebeka Cataldo de Oliveira Fanti, Tatsuya Ikenoue, Rocher Leung, Renu Chandrasekaran, Matthew G. Alteen, Brandon A. Keith, Suzanne Z. Ackloo, A.M. Edwards, Derek Wilson, Hiroaki Suga, Rachel J. Harding

The paper develops macrocyclic peptides that target HAP40, enabling the study of HTT-HAP40 interactions and their role in Huntington's disease.

bioRxiv · Jun 2, 2026 · PreprintMolecular Biology

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space

Eduardo Silva Ramos, Annett Boeddrich, Christian Haenig, Philipp Trepte, Orchid Ammar, Christopher Secker, Oliver Popp, Andranik Ivanov, Brandon A. Keith, Rachel J. Harding, Franziska Schindler, Tomáš Koudelka, Leonard Roth, Nadine Scharek, Martina Zenkner, , Erich E. Wanker

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

bioRxiv · Apr 1, 2026 · PreprintCell Biology

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin

Esther Wolf, Rebeka Cataldo de Oliveira Fanti, Tatsuya Ikenoue, Justin C. Deme, Swati Balakrishnan, Brandon A. Keith, Matthew G. Alteen, Renu Chandrasekaran, Manisha Yadav, Ritika Bhajiawala, Suzanne Z. Ackloo, Feng Jia, Mahmoud A. Pouladi, A.M. Edwards, Derek J. Wilson, , Rachel Harding

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

bioRxiv · Aug 6, 2025 · PreprintBiochemistry