Author

Tiantian Wang

Shandong UniversityORCID 0009-0008-4360-2518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Meixi GongiD· 2 shared Wenfei LiiD· 2 shared Yile ZhaiiD· 2 shared Zhe ZhangiD· 2 shared Jiangxue HaniD· 1 shared Mengxiao Wu· 1 shared Xin WangiD· 1 shared Yuhan Liang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Meixi GongORCID

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2 papers

Recent·Most cited

Cell BiologyPLoS ONEPeer-reviewedOct 27, 2026

POI-associated LMD-3 mutation impairs B12-regulated lysosomal function and reproductive capacity in C. elegans

Yile Zhai, Tiantian Wang, Meixi Gong…·Zhe Zhang

This study shows that the LMD-3 mutation in C. elegans causes reproductive failure by disrupting lysosomal function and proteostasis, which can be reversed with vitamin B12 supplementation.

DOI 10.1371/journal.pone.0361215

C. elegansproteomics

𝕏 PostBluesky

Cell BiologyScience AdvancesPeer-reviewedNov 26, 2025

Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans

Yile Zhai, Tiantian Wang, Jiangxue Han…·Zhe Zhang

This study identifies LMD-3 as a regulator of proteostasis and reproductive capacity in C. elegans, showing its role in lysosomal function and the reversibility of fecundity decline with vitamin B12.

4 citations

C. elegansproteomics

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