Shih Ming Huang

The paper develops and validates a genetically encoded fluorescent sensor, iG6PSnFR, for measuring glucose-6-phosphate dynamics across multiple biological contexts.

The paper shows primary cilia use localized glycolysis and mitochondrial PEP to generate ATP, and can access ATP from the cell body when glucose is limited.

This study shows that the α-cell mitochondrial PEP cycle senses amino acids and regulates Ca2+ levels without affecting glucagon secretion.