David Toppe

The paper investigates the role of hypothalamic NPY/AgRP neurons in regulating age-related presynaptic remodeling through autophagy and non-cell autonomous mechanisms.

This study shows that Bruchpilot remodeling couples synaptic structure to Kv1/Shaker channel control of excitability, restoring function in sleepless mutants.

This study shows that autophagy in Drosophila mushroom bodies regulates synaptic architecture and sleep resilience by modulating presynaptic active zone proteins and triggering a systemic proteostatic stress response.

This study shows that a constitutively active form of Unc13A reduces sleep rebound after deprivation, suggesting a role for SNARE complex dynamics in sleep homeostasis.

The paper shows that insomniac Drosophila mutants exhibit enhanced memory and mushroom body overgrowth, which are modulated by PKA signaling, suggesting a link between cognitive hyperplasticity and sleep deficits.