Sheng Huang

This study shows that Bruchpilot remodeling couples synaptic structure to Kv1/Shaker channel control of excitability, restoring function in sleepless mutants.

The paper shows that presynaptic release probability, not synaptic strength, decreases with sleep loss and affects sleep need across species.

This study shows that autophagy in Drosophila mushroom bodies regulates synaptic architecture and sleep resilience by modulating presynaptic active zone proteins and triggering a systemic proteostatic stress response.

This study shows that a constitutively active form of Unc13A reduces sleep rebound after deprivation, suggesting a role for SNARE complex dynamics in sleep homeostasis.

The paper shows that insomniac Drosophila mutants exhibit enhanced memory and mushroom body overgrowth, which are modulated by PKA signaling, suggesting a link between cognitive hyperplasticity and sleep deficits.

The paper shows that presynaptic active zone plasticity (PreScale) influences brain resilience to aging in Drosophila by linking sleep, memory, and longevity.

The paper identifies delta oscillations in Drosophila's R2 network that regulate sleep, showing synchronization depends on NMDARs and input pathways, and disrupting this mechanism abolishes oscillations and impairs sleep.

The paper identifies a molecular mechanism for presynaptic plasticity involving rapid remodeling of active zone modules, which sustains neurotransmitter release potentiation over time.