Christine Brigitte Beuschel

This study shows that Bruchpilot remodeling couples synaptic structure to Kv1/Shaker channel control of excitability, restoring function in sleepless mutants.

The paper shows that insomniac Drosophila mutants exhibit enhanced memory and mushroom body overgrowth, which are modulated by PKA signaling, suggesting a link between cognitive hyperplasticity and sleep deficits.

The paper shows that presynaptic active zone plasticity (PreScale) influences brain resilience to aging in Drosophila by linking sleep, memory, and longevity.

The paper identifies a molecular mechanism for presynaptic plasticity involving rapid remodeling of active zone modules, which sustains neurotransmitter release potentiation over time.