Author

Julia E. Bonzanini

University of WashingtonORCID 0009-0004-0860-9678Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1

Frequent Co-Authors

Chunyu WangiD· 2 shared David A. BakeriD· 2 shared K. Christopher GarcíaiD· 2 shared Adnane AchouriD· 1 shared Amarachi E. OnwukaiD· 1 shared Amir MotmaeniD· 1 shared Apala ChaudhuriiD· 1 shared Armita NourmohammadiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Chunyu WangORCID

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2 papers

Recent·Most cited

Design of solubly expressed miniaturized SMART MHCs

William L. White, Hua Bai, Chun Kim, Kevin M. Jude, Renhua Sun, Laura Guerrero, Xiao Han, Xiaojing Tina Chen, Apala Chaudhuri, Julia E. Bonzanini, Yi Sun, Amarachi E. Onwuka, Nan Wang, Chunyu Wang, Per‐Åke Nygren, , David A. Baker

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

Proceedings of the National Academy of Sciences · Jan 2, 2026Peer-reviewedBiochemistry

Design of high specificity binders for peptide-MHC-I complexes

Bingxu Liu, Nathan F. Greenwood, Julia E. Bonzanini, Amir Motmaen, Jeremy Meyerberg, Tao Dao, Xinyu Xiang, Russell Ault, Jazmin Sharp, Chunyu Wang, Gian Marco Visani, Dionne K. Vafeados, Nicole Roullier, Armita Nourmohammad, David A. Scheinberg, , David A. Baker

The paper designs high specificity binders for peptide-MHC-I complexes using deep learning, achieving specific targeting of pMHCs and enabling T-cell activation.

Science · Jul 24, 2025Peer-reviewedImmunology