The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetalorgans by single cell transcriptome study
Mengmeng LiiD, Liang CheniD, Jingxiao ZhangiD, Chenglong XiongiD, Xiangjie LiiD
Abstract
Recent studies have demonstrated that SARS-CoV-2 cell entry depends on both ACE2 and TMPRSS2 genes (DOI: 10.1016/j.cell.2020.02.052), but our current work only focus on ACE2, which is insufficient to support the conclusion of this paper. So the authors have withdrawn their manuscript whilst they perform additional experiments and analysis to test some of their conclusions further. Therefore, the authors do not wish this work to be cited as reference for the project.
02 /Specification & Classification
Click any tag to browse matching papers- Citations
- 401
- FWCI
- 55.50
- Field percentile
- top 1%
- Organism
- Assay
- Research Focus
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Roger Piqué-Regi, Roberto J. Romero, … Nardhy Gomez‐Lopez·eLifePeer-reviewed·Jul 13, 2020
- Acute SARS-CoV-2 infection in pregnancy is associated with placental ACE-2 shedding
E. S. Taglauer, E. M. Wachman, … H. Jia·bioRxiv·Nov 19, 2021
- Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex?
Lydia L. Shook, Evan A. Bordt, … Andrea G. Edlow·bioRxiv·Apr 1, 2021
- Single-cell RNA expression profiling of ACE2,thereceptor of SARS-CoV-2
Yu Zhao, Zixian Zhao, … Wei Zuo·American Journal of Respiratory and Critical Care MedicinePeer-reviewed·Jul 14, 2020
- The protein expression profile of ACE2 in human tissues
F. Hikmet, L. Mear, … C. Lindskog·bioRxiv·Mar 31, 2020
- Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells
Flávia Bessi Constantino, Sarah Santiloni Cury, … Luís Antônio Justulin·Frontiers in Molecular BiosciencesPeer-reviewed·Nov 8, 2021