COVID-19 Impact on Reproduction

Trophoblast ferroptosis restricts SARS-CoV-2 spread in the placenta

This study shows that SARS-CoV-2 induces ferroptosis in placental trophoblasts, limiting viral spread but causing iron sequestration that may lead to iron deficiency in infants.

Placentas from SARS-CoV-2 infection during pregnancy exhibit foci of oxidative stress and DNA damage

This study examines placental changes in SARS-CoV-2 infected pregnancies, finding localized oxidative stress and DNA damage without overall senescence differences.

SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids

Whole transcriptome profiling of placental pathobiology in SARS-CoV-2 pregnancies identifies placental dysfunction signatures

This study uses spatial transcriptomics to identify placental dysfunction signatures in SARS-CoV-2 infected pregnancies, revealing altered gene expression related to hypoxia, oxidative stress, and preeclampsia-like pathways.

SARS-CoV-2 Can Infect Human Embryos

This study shows SARS-CoV-2 can infect human embryos, specifically trophectoderm cells in blastocysts, with potential implications for reproductive health.

SARS-CoV-2 impacts the transcriptome and epigenome at the maternal-fetal interface in pregnancy

The paper investigates how SARS-CoV-2 infection alters the transcriptome and epigenome at the maternal-fetal interface, linking these changes to adverse pregnancy outcomes.

Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells

The paper identifies non-canonical mediators of SARS-CoV-2 infection in placental cells through transcriptomic analysis.

Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex?

The paper examines placental ACE2 and TMPRSS2 expression in relation to maternal SARS-CoV-2 infection and fetal sex, finding sexually dimorphic effects on TMPRSS2 but not ACE2.

Comprehensive evaluation of ACE2 expression in female ovary by single-cell RNA-seq analysis

This study uses single-cell RNA-seq to evaluate ACE2 expression in ovarian tissues across developmental stages, identifying high ACE2 expression in PGCs and COC and its potential role in SARS-CoV-2 infection risk.

Female reproductive tract has low concentration of SARS-CoV2 receptors

The paper investigates SARS-CoV2 receptor expression in female reproductive tissues and finds no significant ACE2 or TMPRSS2 expression, suggesting low susceptibility to infection.

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

The paper investigates ACE2 and TMPRSS2 expression in human placenta across pregnancy stages and finds negligible co-expression, suggesting SARS-CoV-2 is unlikely to infect placenta via canonical entry mediators.

The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetalorgans by single cell transcriptome study

The paper investigates ACE2 expression in maternal-fetal interface and fetal organs using single-cell transcriptomics but was withdrawn due to insufficient analysis of ACE2 and TMPRSS2.