Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations

Joseph S. Reddy; Laura M. Heath; Abby Vander Linden; Mariet Allen; Kátia de Paiva Lopes; Fatemeh Seifar; Erming Wang; Yiyi Ma; William L. Poehlman; Zachary Quicksall; Alexi M. Runnels; Yanling Wang; Duc M. Duong; Luming Yin; Kaiming Xu; Erica S. Modeste; Anantharaman Shantaraman; Eric B. Dammer; Lingyan Ping; Stephanie R. Oatman; Jo Scanlan; Charlotte C.G. Ho; Minerva M. Carrasquillo; Merve Atık; Geovanna Yepez; Adriana O. Mitchell; Thuy Nguyen; Xianfeng Chen; David X. Márquez; Hasini Reddy

doi:10.1002/alz.14208

NeuroscienceAlzheimer s & DementiaAug 30, 2024

Peer-reviewed journal article

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations

Joseph S. Reddy iD, Laura M. Heath iD, Abby Vander Linden iD, Mariet Allen iD, Kátia de Paiva Lopes iD, Fatemeh Seifar iD, Erming Wang iD, Yiyi Ma iD, William L. Poehlman iD, Zachary Quicksall iD, Alexi M. Runnels iD, Yanling Wang iD, Duc M. Duong iD, Luming Yin, Kaiming Xu iD, Erica S. Modeste iD, Anantharaman Shantaraman iD, Eric B. Dammer iD, Lingyan Ping iD, Stephanie R. Oatman, Jo Scanlan, Charlotte C.G. Ho iD, Minerva M. Carrasquillo iD, Merve Atık, Geovanna Yepez, , Nilüfer Ertekin‐Taner iD

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Abstract

INTRODUCTIONMulti-omics studies in Alzheimers disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked African Americans (AA) and Latin Americans (LA), who are disproportionately affected by AD. METHODSTo bridge this gap, Accelerating Medicines Partnership in AD (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors. RESULTSWe generated multi-omics data and curated and harmonized phenotypic data from AA (n=306), LA (n=326), or AA and LA (n=4) brain donors plus Non-Hispanic White (n=252) and other (n=20) ethnic groups, to establish a foundational dataset enriched for AA and LA participants. This study describes the data available to the research community, including transcriptome from three brain regions, whole genome sequence, and proteome measures. DISCUSSIONInclusion of traditionally underrepresented groups in multi-omics studies is essential to discover the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD.