bioRxivEvolutionary Biology
Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models
R. O. Schenck, G. Brosula, J. West, S. Leedham, D. Shibata, A. R. Anderson
Abstract
Gattaca provides the first base-pair resolution artificial genomes for tracking somatic mutations within agent based modeling. Through the incorporation of human reference genomes, mutational context, sequence coverage/error information Gattaca is able to realistically provide comparable sequence data for in-silico comparative evolution studies with human somatic evolution studies. This user-friendly method, incorporated into each in-silico cell, allows us to fully capture somatic mutation spectra and evolution.
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