Author

S. Leedham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

R. O. Schenck· 3 shared A. R. A. Anderson· 2 shared A.-M. Baker· 2 shared C. D. Gatenbee· 2 shared D. Shibata· 2 shared J. West· 2 shared M. Robertson-Tessi· 2 shared T. A. Graham· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersEvolutionary Biology

R. O. Schenck

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Author profile →

6 papers

Recent·Most cited

Niche conservatism in a generalist felid: low differentiation of the climatic niche among subspecies of the leopard (Panthera pardus)

S. Leedham, J. L. A. Paijmans, A. Manica, M. Leonardi

This study uses species distribution models to compare the climatic niches of leopard subspecies, finding low differentiation and suggesting niche conservation despite geographic dispersal.

bioRxiv · Jan 26, 2023 · PreprintEcology

Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data

N. C. Fisher, R. Byrne, H. Leslie, C. Wood, A. Legrini, A. Cameron, B. Ahmaderaghi, S. Corry, S. Malla, R. Amirkhah, A. McCooey, E. Rogan, K. Redmond, S. Sakhnevych, E. Domingo, , P. D. Dunne

The paper shows that transcriptional signatures in tumour samples can be misinterpreted due to stromal influences, affecting alignment with preclinical data.

bioRxiv · Apr 15, 2022 · PreprintCancer Biology

VALIS: Virtual Alignment of pathoLogy Image Series

C. D. Gatenbee, A.-M. Baker, S. Prabhakaran, R. J. C. Slebos, G. Mandal, E. Mulholland, S. Leedham, J. R. Conejo-Garcia, C. H. Chung, M. Robertson-Tessi, T. A. Graham, A. R. A. Anderson

VALIS automates registration of immunohistochemistry and immunofluorescence images, enabling spatial analysis of whole slide images with low error and minimal computational time.

bioRxiv · Nov 9, 2021 · PreprintCancer Biology

Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models

R. O. Schenck, G. Brosula, J. West, S. Leedham, D. Shibata, A. R. Anderson

Gattaca generates base-pair resolution artificial genomes to track somatic mutations in agent-based models, enabling in-silico studies comparable to human somatic evolution.

bioRxiv · Nov 8, 2021Evolutionary Biology

How Homeostasis Limits Keratinocyte Evolution

R. O. Schenck, E. Kim, R. Bravo, J. West, S. Leedham, D. Shibata, A. R. A. Anderson

This study presents a mechanistic epidermal model showing homeostasis leads to log-linear subclone size distributions in skin cells, with larger subclones being older due to persistence of driver mutations.

bioRxiv · Jun 25, 2019 · PreprintEvolutionary Biology

Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

C. D. Gatenbee, A.-M. Baker, R. O. Schenck, M. Neves, S. Y. Hasan, P. Martinez, W. C. H. Cross, M. Jansen, M. Rodriguez-Justo, A. Sottoriva, S. Leedham, M. Robertson-Tessi, T. A. Graham, A. Anderson

The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.

bioRxiv · May 3, 2019 · PreprintCancer Biology