Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling

Introductory Paragraph Introductory Paragraph Materials and Methods tir-1 3'UTR mutant tir-1::gfp CrispR/Cas9 repair templates References The maintenance of proteostasis is crucial for any organism to survive and reproduce in an ever-changing environment, but its efficiency declines with age1,2. Posttranscriptional regulators such as microRNAs control protein translation of target mRNAs with major consequences for development, physiology, and longevity3,4. However, the precise function of lifespan- determining microRNAs remains poorly understood. Here we show that the microRNA mir-71 controls organismal proteostasis and aging in Caenorhabditis elegans by regulating its conserved target tir-1 in AWC ol ...