bioRxivGeneticsPreprint
Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
Εvangelos ΕvangelouiD, He GaoiD, Congying ChuiD, Georgios NtritsosiD, Paul BlakeleyiD, Andrew R. ButtsiD, Raha PazokiiD, Hideaki SuzukiiD, Fotios KoskeridisiD, Andrianos M. Yiorkas, İbrahim KaramaniD, Joshua ElliottiD, Stefanie AeschbacheriD, Traci M. BartziD, Sebastian Edgar BaumeisteriD, Peter S. BraundiD, Michael R. BrowniD, Jennifer A. BrodyiD, Toni‐Kim ClarkeiD, Niki L. DimouiD, Jessica D. FauliD, Georg HomuthiD, Anne JacksoniD, Katherine A. KentistouiD, Peter K. JoshiiD, , Paul ElliottiD
Abstract
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a genome-wide association study (GWAS) of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila. Our results identify new genetic pathways associated with alcohol consumption and suggest common genetic mechanisms with several neuropsychiatric disorders including schizophrenia.
- organism: Drosophila
- assay: GWAS summary statistics
- research focus: GWAS / association mapping
- approach: statistical model
- Citations
- 2
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